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1 CBD Questions
1.1 How Does CBD Work?

Cannabidiol (CBD), a non-intoxicating component of the cannabis plant, has generated significant interest among scientists and physicians in recent years—but how CBD exerts its therapeutic impact on a molecular level is still being sorted out. Cannabidiol is a pleiotropic drug in that it produces many effects through multiple molecular pathways. The scientific literature has identified more than 65 molecular targets of CBD.

Although CBD has little binding affinity for either of the two cannabinoid receptors (CB1 and CB2), cannabidiol modulates several non-cannabinoid receptors and ion channels. CBDalso acts through various receptor-independent pathways—for example, by delaying the “reuptake” of endogenous neurotransmitters (such as anandamide and adenosine) and by enhancing or inhibiting the binding action of certain G-protein coupled receptors.

1.2 How Much CBD Is The Correct Dosage

We have outlined suggested guidelines for our Hemp Oil Tinctures (150mg, 300mg, 450mg, 900mg) and the Full-Spectrum Water Soluble Hemp Oil (300mg, 600mg, 900mg).

Click Here for the Hemp Oil Tincture Dosage

Click Here for the Water Soluble Dosage

 

Of course you should seek out your medical professional before starting any CBD program.

Please contact us at columbineoilsllc@gmail.com if you have any questions.

1.3 Is CBD Legal?

In 2016, the Drug Enforcement Agency (DEA) created a new coding category to classify “marihuana extracts” like CBD, but in doing so made clear that CBD was still classified as a Schedule I drug and therefore still illegal. Although the 2018 FDA approval of Epidiolex meant that the DEA removed this specific CBD drug from Schedule I classification, all other non-FDA approved forms for CBD remained classified as Schedule I drugs.

Now, with the passing of the new 2018 Farm Bill, hemp and hemp-derived products have been officially removed from the purview of the Controlled Substances Act, such that they are no longer subject to Schedule I status. Meaning that so long as CBD is extracted from hemp and completely pure (without any THC — something the DEA doubts is possible) and grown by licensed farmers in accordance with state and federal regulations, it is legal as a hemp product.

But in response to the 2018 Farm Bill, the FDA issued a statement noting that the new legislation preserves the FDA’s authority to regulate cannabis and cannabis-derived compounds like CBD, regardless of its source. It also voiced specific concerns about unsubstantiated health-related CBD claims and iterated the unlawfulness of marketing CBD as a dietary supplement or adding it into food products (read the full FDA statement here). So while hemp cultivation and the extraction of CBD from it may now be legal, what the federal government will allow to be done with CBD products from that point on remains to be seen.

1.4 What is CannaBiDiol?

 Cannabidiol is a phytocannabinoid discovered in 1940. It is one of some 113 identified cannabinoids in Cannabis plants, accounting for up to 40% of the plant's extract. As of 2018, preliminary clinical research on cannabidiol included studies of anxiety, cognition, movement disorders, and pain.

1.5 Will I Test Positive On A Drug Test?

We must first preface any answer to this type of question to say that we are not lawyers nor doctors and cannot provide legal or medical advice.

Most employers performing a drug screening will use the SAMHSA (Substance Abuse and Mental Health Services Administration) guidelines. These guidelines specify an initial urine test for the analyse THC (the psychoactive compound). Other non-psychoactive cannabinoids (CBD, CBN, CBG, etc) will not typically be identified in this test.

If a test looks for all cannabinoids or comes back positive the SAMHSA guidelines specify a more accurate GC/MS analysis be performed to eliminate any potential for false positive results from the urine analysis. In a GC/MS analysis, the molecule differences between CBD and THC are easily identified.
You must consult your employer’s guidelines and acceptance criteria for their definition of what is considered illegal drug use. Some companies may include all cannabinoids in their policy, which can impact drug testing results for CBD users.

An additional note: many testing agencies use a test similar to the one that can be bought at any local drug store.
Additionally, research suggests that people who use a very high amount of CBD or any cannabinoid, can test positive because cannabinoids can build up over time. A high amount, in this research, was defined as 100's of milligrams of product daily.

As a word of caution, no matter what CBD product you take, always make sure you see the labs for potency and make sure the product is .3% or less THC.

2 How Much CBD Should I Take?
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